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AŞILARI KARŞILAŞTIR | Biontech mi Sinovac mı hangisi daha güvenli? Hangi aşıyı seçmeliyim? Biontech mi Sinovac mı daha iyi ve daha etkili? BioNTech- Sinovac nerenin aşısı, yan etkileri kaç gün?


SINOVAC VE BIONTECH ARASINDAKİ FARK NEDİR? || AŞILAR ARASINDAKİ FARKLAR

Erken dönemde faz III çalışmalarına başlamış beş aşı, üç farklı yöntemle üretilmektedir.

Bu yöntemler:

1.İnaktif Aşılar
●Gelenekselleşmiş yöntemlerle üretilir.
●Virüs parçalanıp etkisiz hale getirilerek vücudumuza zarar verilmeden bağışıklığımız uyarılır.
●Uzun dönem etkileri konusunda diğer aşılara kıyasla daha net konuşulabilir.
●Öldürülmüş virüs ihtiva etmelerinden dolayı ilk aşamada daha güvenli olduğu kabul edilir.
●2-8°C’de saklanabilir.
●Üretimi diğerlerine göre daha zor ve yavaştır.
●Türkiye’de yapılan faz III çalışmasının ara değerlendirme sonuçlarına göre aşının etkinliği %91,25 olarak tespit edilmiştir.
●Sinovac aşısı bu sınıfa girmektedir.

2.Viral Vektör (Adenovirüs) Aşıları
●Grip benzeri hastalık yapan bir virüsün (adenovirüs) genetik müdahale sonrası Koronavirüs proteini ile desteklenerek insanda bağışıklık oluşturması amaçlanır.
●Bu aşılar; Zika, Chikungunya gibi viral hastalıklara karşı uzun bir süredir faz III aşamasındaydı.
●Aşıların içindeki mikroorganizmalar canlı olmakla birlikte, güçsüzleştirildiklerinden dolayı insanlarda hastalık yapamazlar.
●Avantajı 2-8°C arasında, yani rutin olarak kullanılan aşı dolaplarında saklanabilmeleridir.
●Yeni aşı geliştirme teknolojilerindendir.
●Sputnik-V ve Oxford/AstraZeneca aşıları (AZA-1222) bu sınıfa girmektedir.

3.Mesajcı RNA (mRNA) Aşıları
●mRNA, vücudumuzda doğal olarak üretilen protein sentezinde rol alır.
●Laboratuvarda yapay olarak üretilen mRNA’lar tıpkı kendi mRNA’larımız gibi çalışarak virüse karşı bizi uyarmayı amaçlamaktadır.
●Bu moleküller daha sonra kendi moleküllerimiz gibi yıkılarak vücuttan atılırlar.
●Bu aşılar 25 yıldır kanser dâhil pek çok hastalığın tedavisine yönelik olarak kişiye özel immunoterapi yöntemleriyle çalışılan teknolojiye benzer şekilde üretilen aşılardır.
●Bu aşıların en büyük dezavantajı Biontech/Pfizer aşısının (BNT-162b2) -70°C’de, Moderna aşısının (mRNA-1273) -20°C’de saklanabiliyor olmasıdır.
●Biontech/Pfizer, Moderna aşıları bu sınıfa girmektedir.

* Ülkemizde halen 16 aşıya ilişkin çalışma yürütülmektedir.



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